Article
Targeting Wnt Signaling: Can We Safely Eradicate Cancer Stem Cells?
9 Jun 2010
Abstract excerpt
The Wnt signaling pathways have been conserved throughout evolution and regulate cell proliferation, morphology, motility, and fate during embryonic development. These pathways also play important roles throughout adult life to maintain homeostasis of tissues including skin, blood, intestine, and brain by regulating somatic stem cells and their niches. Aberrant regulation of the Wnt pathway leads to neoplastic...
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