Article

Targeting Wnt Signaling To Overcome PARP Inhibitor Resistance

2018-07-27

Abstract excerpt

<h4>ABSTRACT</h4> Epithelial ovarian cancer (EOC) has one of the highest deaths to incidence ratios. High grade serous ovarian carcinoma (HGSOC) is the most common and deadliest EOC histotype because of the lack of secondary therapeutic options following debulking surgery and platinum/taxane-based chemotherapies. For recurrent chemosensitive HGSOC, poly(ADP)-ribose polymerase inhibitors (PARPi; olaparib, rucapari...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9899bf23-2c1b-574a-b571-5c015fb4e1a3
DOI: 10.1101/378463

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Targeting Wnt Signaling To Overcome PARP Inhibitor ResistanceDOI 10.1101/378463Read

Activation of Wnt signaling promotes olaparib resistant ovarian cancerSemantic proximity Read

Treatment of Ovarian Cancer Beyond PARP Inhibition: Current and Future OptionsSemantic proximity Read

Efficacy and Mechanism of the Combination of PARP and CDK4/6 Inhibitors in the Treatment of Triple-negative Breast CancerSemantic proximity Read

PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapySemantic proximity Read

Characterization of a RAD51C -silenced high-grade serous ovarian cancer model during development of PARP inhibitor resistanceSemantic proximity Read

Efficacy and mechanism of the combination of PARP and CDK4/6 inhibitors in the treatment of triple-negative breast cancerSemantic proximity Read

ATF6-Mediated Signaling Contributes to PARP Inhibitor Resistance in Ovarian CancerSemantic proximity Read

Demethylating agents drive PARP inhibitor resistance in ovarian carcinomas with BRCA1 gene silencingSemantic proximity Read

Ovarian cancer recurrence: “is the definition of platinum resistance modified by PARP inhibitors and other intervening treatments?”Semantic proximity Read

Reversing Platinum Resistance in High-Grade Serous Ovarian Carcinoma: Targeting BRCA and the Homologous Recombination SystemSemantic proximity Read

Platinum and PARP Inhibitor Resistance Due to Overexpression of MicroRNA-622 in BRCA1-Mutant Ovarian CancerSemantic proximity Read

Repression of PFKFB3 sensitizes ovarian cancer to PARP inhibitors by impairing homologous recombination repairSemantic proximity Read