Article
PTEN Dephosphorylates BECLIN-1 to Regulate Serum-Dependent Autophagy in Thyroid Cancer Cells
2026-02-12
Abstract excerpt
PTEN is a well-established tumor suppressor that plays a central role in the regulation of cell growth, metabolism, and survival. As a protein-lipid dual phosphatase, PTEN negatively regulates the PI3K/AKT signaling pathway, which in turn modulates autophagy, a conserved catabolic process that allows cells to degrade and recycle intracellular components, through the downstream effector mTORC1. While this represent...
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Identifiers and source
- Literature Corpus work
- 9a7b5741-6736-533a-91d5-cbe4f7e5a360
- DOI
- 10.20944/preprints202602.0593.v2