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Article

A conserved molecular switch in Class F receptors regulates receptor activation and pathway selection

8 Feb 2019

Abstract excerpt

Abstract Class F receptors are considered valuable therapeutic targets due to their role in human disease, but structural changes accompanying receptor activation remain unexplored. Employing population and cancer genomics data, structural analyses, molecular dynamics simulations, resonance energy transfer-based approaches and mutagenesis, we identify a conserved basic amino acid in TM6 in Class F receptors that...

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PMID: 30737406
DOI: 10.1038/s41467-019-08630-2

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