Article

Comparative Temporal Transcriptomic Analysis of SOD1 Mutations in iPSC-Motor Neurons

2025-08-23

Abstract excerpt

Mutations in the SOD1 gene are among the most significant genetic contributors to amyotrophic lateral sclerosis (ALS), with different variants linked to varying disease severity. To investigate the molecular mechanisms driving this variability, we conducted RNA sequencing on spinal motor neurons (MNs) differentiated from isogenic human induced pluripotent stem cell (iPSC) lines engineered via CRISPR/Cas9. These li...

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Literature Corpus work: 9a5b2938-a273-5ce1-b62a-7254ecc5750c
DOI: 10.1101/2025.08.19.670632

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