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Article

Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons.

International journal of molecular sciences - 25 Aug 2022

Dash Banaja P, Freischmidt Axel, Weishaupt Jochen H, Hermann Andreas

Abstract excerpt

Amyotrophic Lateral Sclerosis (ALS) is a progressive and fatal neurodegenerative disease marked by death of motor neurons (MNs) present in the spinal cord, brain stem and motor cortex. Despite extensive research, the reason for neurodegeneration is still not understood. To generate novel hypotheses of putative underlying molecular mechanisms, we used human induced pluripotent stem cell (hiPSCs)-derived motor...

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Identifiers

PMID: 36077049
DOI: 10.3390/ijms23179652
PMCID: PMC9456253

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