Article

Early alterations of RNA metabolism and splicing from adult corticospinal neurons in an ALS mouse model

2019-06-12

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease clinically defined as the combined degeneration of corticospinal and corticobulbar neurons (CSN), and bulbar and spinal motor neurons (MN). A growing body of evidence points to the motor cortex, where CSN are located, as the potential initiation site of ALS. However, little is known about the spatiotemporal dynamics of CSN degeneration...

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Literature Corpus work: 92189232-3cfb-5799-8293-4793f523bfa9
DOI: 10.1101/667733

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