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Neuronal mitochondrial dysfunction in sporadic amyotrophic lateral sclerosis is developmentally regulated

23 Sept 2021

Abstract excerpt

Amyotrophic lateral sclerosis is an adult-onset neurodegenerative disorder characterized by loss of motor neurons. Mitochondria are essential for neuronal survival but the developmental timing and mechanistic importance of mitochondrial dysfunction in sporadic ALS (sALS) neurons is not fully understood. We used human induced pluripotent stem cells and generated a developmental timeline by differentiating sALS...

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PMID: 34556702
DOI: 10.1038/s41598-021-97928-7

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