Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse.

PloS one - 1 Jan 2013

Bandyopadhyay Urmi, Cotney Justin, Nagy Maria, Oh Sunghee, Leng Jing, Mahajan Milind, Mane Shrikant, Fenton Wayne A, Noonan James P, Horwich Arthur L

Abstract excerpt

Mechanisms involved with degeneration of motor neurons in amyotrophic lateral sclerosis (ALS; Lou Gehrig's Disease) are poorly understood, but genetically inherited forms, comprising ~10% of the cases, are potentially informative. Recent observations that several inherited forms of ALS involve the RNA binding proteins TDP43 and FUS raise the question as to whether RNA metabolism is generally disturbed in ALS....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis
Share to Lasers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Neurons

Share to Polyadenylation

Share to Sequence Analysis, RNA

Share to Spinal Cord

Share to Superoxide Dismutase

Share to Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 23301088
DOI: 10.1371/journal.pone.0053575
PMCID: PMC3536741

Genes

SOD1
FUS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

RNA-Seq profiling of spinal cord motor neurons from a presymptomatic SOD1 ALS mouse.PMID 23301088Read ↗

Early alterations of RNA metabolism and splicing from adult corticospinal neurons in an ALS mouse modelSemantic proximity Read ↗

Downstream Effects of Mutations in SOD1 and TARDBP Converge on Gene Expression Impairment in Patient-Derived Motor Neurons.Semantic proximity Read ↗

Comparative Temporal Transcriptomic Analysis of SOD1 Mutations in iPSC-Motor NeuronsSemantic proximity Read ↗

Proteomics analysis of FUS mutant human motoneurons reveals altered regulation of cytoskeleton and other ALS-linked proteins via 3'UTR binding.Semantic proximity Read ↗

ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS modelsSemantic proximity Read ↗

RNA Dysregulation in Amyotrophic Lateral SclerosisSemantic proximity Read ↗

RNA Is a Double-Edged Sword in ALS PathogenesisSemantic proximity Read ↗

Characterization of the lncRNA transcriptome in mESC-derived motor neurons: Implications for FUS-ALSSemantic proximity Read ↗

Comparison of independent screens on differentially vulnerable motor neurons reveals alpha-synuclein as a common modifier in motor neuron diseases.Semantic proximity Read ↗

RNA metabolism in ALS: When normal processes become pathologicalSemantic proximity Read ↗

Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALSSemantic proximity Read ↗

Linking amyotrophic lateral sclerosis and spinal muscular atrophy through <scp>RNA</scp>‐transcriptome homeostasis: a genomics perspectiveSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.