Article
Hyperactivity and attention deficits in mice with decreased levels of stress-inducible phosphoprotein 1 (STIP1).
Disease models & mechanisms - 1 Nov 2015
Beraldo Flavio H, Thomas Anu, Kolisnyk Benjamin, Hirata Pedro H, De Jaeger Xavier, Martyn Amanda C, Fan Jue, Goncalves Daniela F, Cowan Matthew F, Masood Talal, Martins Vilma R, Gros Robert, Prado Vania F, Prado Marco A M
Abstract excerpt
Stress-inducible phosphoprotein I (STIP1, STI1 or HOP) is a co-chaperone intermediating Hsp70/Hsp90 exchange of client proteins, but it can also be secreted to trigger prion protein-mediated neuronal signaling. Some mothers of children with autism spectrum disorders (ASD) present antibodies against certain brain proteins, including antibodies against STIP1. Maternal antibodies can cross the fetus blood-brain...
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