Article

Ligation-anchored PCR unveils immune repertoire of TCR-beta from whole blood

2014-07-11

Abstract excerpt

<h4>Background</h4> As one of the genetic mechanisms for adaptive immunity, V(D)J recombination generates an enormous repertoire of T-cell receptors (TCRs). With the development of high-throughput sequencing techniques, systematic exploration of V(D)J recombination becomes possible. Multiplex PCR method has been previously developed to assay immune repertoire, however the usage of primer pools has inherent bias i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9a14c484-4e03-51d9-94bc-61ac32b13e34
DOI: 10.1101/007062

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Ligation-anchored PCR unveils immune repertoire of TCR-beta from whole bloodDOI 10.1101/007062Read

A new high-throughput sequencing method for determining diversity and similarity of T cell receptor (TCR) α and β repertoires and identifying potential new invariant TCR α chains.Semantic proximity Read

Human TCR repertoire in cancerSemantic proximity Read

Analysis of the Repertoire Features of TCR Beta Chain CDR3 in Human by High-Throughput Sequencing.Semantic proximity Read

Profiling tissue-resident T cell repertoires by RNA sequencingSemantic proximity Read

An open protocol for modeling T Cell Clonotype repertoires using TCRβ CDR3 sequencesSemantic proximity Read

High Throughput Sequencing of T Cell Antigen Receptors Reveals a Conserved TCR Repertoire.Semantic proximity Read

Systematic Comparative Evaluation of Methods for Investigating the TCRβ RepertoireSemantic proximity Read

High-resolution analysis of the human T-cell receptor repertoire.Semantic proximity Read

The Diagnostic, Prognostic, and Therapeutic Potential of Adaptive Immune Receptor Repertoire Profiling in CancerSemantic proximity Read

Characteristics of profiling the peripheral blood T‐cell receptor repertoire in patients with diffuse large B-cell lymphomaSemantic proximity Read

Profiling the T-cell receptor beta-chain repertoire by massively parallel sequencing.Semantic proximity Read

Systematic profiling of full-length immunoglobulin and T-cell receptor repertoire diversity in rhesus macaque through long read transcriptome sequencingSemantic proximity Read