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Profiling tissue-resident T cell repertoires by RNA sequencing

30 Nov 2015

Abstract excerpt

Deep sequencing of recombined T cell receptor (TCR) genes and transcripts has provided a view of T cell repertoire diversity at an unprecedented resolution. Beyond profiling peripheral blood, analysis of tissue-resident T cells provides further insight into immune-related diseases. We describe the extraction of TCR sequence information directly from RNA-sequencing data from 6738 tumor and 604 control tissues,...

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PMID: 26620832
DOI: 10.1186/s13073-015-0248-x

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