Article

Kilobase-scale compartments enabled by CRUSH reveal regulatory programs across cell types, single-cells, and ancient mammoths

2026-04-28

Abstract excerpt

How chromatin is spatially organized in the nucleus has long been studied through the lens of large-scale A/B compartments, but whether these sizes reflect true biological units or analytical artifacts has remained unclear. We find that limits imposed by the conventional eigenvector-based compartment calling have required extreme sequencing depth and coarse resolution, obscuring regulatory-scale organization. We d...

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Literature Corpus work: fdab2d12-471d-5bdc-a0d2-8d5f122feb83
DOI: 10.64898/2026.04.25.719469

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