Structure-Based Discovery of a Cryptic Druggable Pocket in TP53 C238Y: Implications for Targeted Therapy

Abstract excerpt

<title>Abstract</title> <p>Mutations in the TP53 gene are frequently found in many different types of human cancers These mutations interfere with important functions that normally prevent tumors, like controlling cell growth and causing programmed cell death. When TP53 can't do its job, cells start multiplying without control, and the cell's genetic material becomes unstable. Even though TP53 has long been known...

Topics

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• Binding Sites
• DNA
• Molecular Dynamics Simulation
• Point Mutation
• Protein Binding
• Protein Stability
• Thermodynamics
• Tumor Suppressor Protein p53

Identifiers and source

Literature Corpus work

99ffe74d-da91-5d0e-b5c7-713f4adb443a

DOI

10.21203/rs.3.rs-6370188/v1