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Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting

31 Jan 2019

Abstract excerpt

The transcription factor p53 plays pivotal roles in numerous biological processes, including the suppression of tumours. The rich availability of biophysical data aimed at understanding its structure-function relationships since the 1990s has enabled the application of a variety of computational modelling techniques towards the establishment of mechanistic models. Together they have provided deep insights into...

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PMID: 30726928
DOI: 10.1093/jmcb/mjz009

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