Targeting Mutant-p53 for Cancer Treatment: Are We There Yet?

doi:10.2174/1874467217666230914090621

Article

Targeting Mutant-p53 for Cancer Treatment: Are We There Yet?

15 Sept 2023

Abstract excerpt

BACKGROUND: Mutations in the TP53 gene are the most common among genetic alterations in human cancers, resulting in the formation of mutant p53 protein (mutp53). Mutp53 promotes proliferation, migration, invasion, and metastasis in cancer cells. Not only does the initiation of oncogenesis ensue due to mutp53, but resistance towards chemotherapy and radiotherapy in cancer cells also occurs. This review aims to...

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