Article

Hypoxia-induced Preadipocyte factor 1 expression in human lung fibroblasts through ERK/PEA3/c-Jun pathway

2021-04-12

Abstract excerpt

<title>Abstract</title> <p>Background Several studies have reported that hypoxia plays a pathological role in severe asthma and tissue fibrosis. Our previous study showed that hypoxia induces A disintegrin and metalloproteinase 17 (ADAM17) expression in human lung fibroblasts. Moreover, preadipocyte factor 1 (Pref-1) is cleaved by ADAM17, which participates in adipocyte differentiation. Furthermore, Pref1 overe...

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Literature Corpus work: 99ebfba5-726a-5da9-be82-8ebb1d755533
DOI: 10.21203/rs.3.rs-400752/v1

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