Article

TGF-β-induced α-SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells

2021-02-12

Abstract excerpt

<title>Abstract</title> <p><bold>Background:</bold> Although the morbidity and mortality rates associated with idiopathic pulmonary fibrosis (IPF) are high, there is still lack of powerful and precise therapeutic options for IPF. Object: Through in vitro model,<bold> </bold>this study sought to determine whether binding of acetylated CCAAT/enhancer binding protein β (C/EBPβ) to alpha-smooth muscle actin (α-SMA) p...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9287fd90-62e6-55f3-9dff-77001ca2ed38
DOI: 10.21203/rs.3.rs-76632/v3

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TGF-β-induced α-SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cellsDOI 10.21203/rs.3.rs-76632/v3Read

TGF-β-induced α-SMA expression is mediated by C/EBPβ acetylation in human alveolar epithelial cells in vitroSemantic proximity Read

C/EBPβ Acetylation is Involved in Idiopathic Pulmonary FibrosisSemantic proximity Read

Abrogation of TGF-beta1-induced fibroblast-myofibroblast differentiation by histone deacetylase inhibition.Semantic proximity Read

C/EBPβ: The structure, regulation, and its roles in inflammation-related diseasesSemantic proximity Read

MeCP2 epigenetically regulates alpha‐smooth muscle actin in human lung fibroblastsSemantic proximity Read

Myocardin-related Transcription Factor-A Complexes Activate Type I Collagen Expression in Lung FibroblastsSemantic proximity Read

HDAC8-Selective Inhibition by PCI-34051 Attenuates Inflammation and Airway Remodeling in Asthma via miR-381-3p-TGFβ3 axisSemantic proximity Read

Amplification of TGFβ Induced ITGB6 Gene Transcription May Promote Pulmonary FibrosisSemantic proximity Read

TGFβ-induced fibroblast activation requires persistent and targeted HDAC-mediated gene repressionSemantic proximity Read

Rev-erbα agonists suppresses TGFβ1-induced fibroblast-to-myofibroblast transition and pro-fibrotic phenotype in human lung fibroblasts.Semantic proximity Read

Histone deacetylase 4 is required for TGFβ1-induced myofibroblastic differentiationSemantic proximity Read

NAT10-mediated RNA ac4C acetylation contributes to the myocardial infarction induced cardiac fibrosisSemantic proximity Read