STAT3 Facilitates Super Enhancer Formation to Promote Fibroblast‐To‐Myofibroblast Differentiation by the Analysis of ATAC ‐Seq, RNA ‐Seq and ChIP ‐Seq

Abstract excerpt

A cellular characteristic of IPF is the transformation of fibrosis into myofibroblasts. This study identifies several transcription factors-STAT3, FOXP1, JUNB, ATF3, FosL2, BATF, Fra2 and AP-1-that play crucial roles in promoting pulmonary fibrogenesis. They achieve this by facilitating the differentiation of fibroblasts into myofibroblasts, as analysed through ATAC-seq and RNA-seq. Additionally, STAT3 ChIP-seq...

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