Article

Disrupting the Complex BMP/TGF-β Signaling Pathway: Modulation of AQP1 and TGFB1 in Human Pulmonary Microvascular Endothelial Cells

2025-06-09

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a chronic disorder with high fatality rates, and its progression is highly associated with the genetic background. Alongside pathogenic variants in genes central to the BMP/TGF-β signaling pathway, recent evidence has linked aquaporin 1 (AQP1) gene variants to PAH. While BMP9 shows promise as a PAH therapy, emerging conflicting evidence challenges this prospect. Herein, we...

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Literature Corpus work: 99e03968-4cb1-50aa-8edf-29ac51d6c83c
DOI: 10.20944/preprints202506.0616.v1

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