Article
Transforming growth factor beta/bone morphogenic protein signaling in pulmonary arterial hypertension: remodeling revisited.
Trends in cardiovascular medicine - 1 Nov 2007
Eickelberg Oliver, Morty Rory E
Abstract excerpt
Growth factors of the transforming growth factor (TGF) beta superfamily have emerged as important regulators of normal cardiovascular development, as well as modulators of the onset or progression of vascular diseases. Recently, familial and idiopathic pulmonary arterial hypertension (IPAH) has been causally linked to somatic and genetic perturbations to the TGF-beta/bone morphogenic protein (BMP) system,...
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