Article

Effects of Modulating BMP9, BMPR2, and AQP1 on Bmp-Signaling in Human Pulmonary Microvascular Endothelial Cells

2024-07-01

Abstract excerpt

Pulmonary arterial hypertension (PAH) is a chronic disease characterized by a progressive in-crease in mean pulmonary arterial pressure. Mutations in the BMPR2 and AQP1 genes have been described in familial PAH. The bone morphogenetic proteins BMP9 and BMP10 bind with high affinity to BMPR2. Administration of BMP9 has been proposed as a potential therapeutic strategy against PAH, although recent conflicting eviden...

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Literature Corpus work: d7ead83e-c82a-5747-96ee-f6d606c674f1
DOI: 10.20944/preprints202407.0057.v1

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