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Article

Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3.

American journal of respiratory cell and molecular biology - 1 Dec 2013

Upton Paul D, Davies Rachel J, Tajsic Tamara, Morrell Nicholas W

Abstract excerpt

Previous studies of pulmonary arterial hypertension (PAH) have implicated excessive transforming growth factor (TGF)-β1 signaling and reduced bone morphogenetic protein (BMP) signaling in the disease pathogenesis. Reduced BMP signaling in pulmonary artery smooth muscle cells (PASMCs) from patients with heritable PAH is a consequence of germline mutations in the BMP type II receptor (BMPR-II). We sought to...

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Share to Bone Morphogenetic Protein 4
Share to Bone Morphogenetic Protein Receptors, Type II

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Familial Primary Pulmonary Hypertension

Share to Hypertension, Pulmonary

Share to Pulmonary Artery

Share to Receptor, Transforming Growth Factor-beta Type I

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Source

Open in PubMed Open full text

Identifiers

PMID: 23937428
DOI: 10.1165/rcmb.2012-0470OC
PMCID: PMC3931109

Genes

BMP4
PAH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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