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Article

BMPR2 gene delivery reduces mutation-related PAH and counteracts TGF-β-mediated pulmonary cell signalling.

Respirology (Carlton, Vic.) - 1 Apr 2016

Feng Feng, Harper Rebecca L, Reynolds Paul N

Abstract excerpt

BACKGROUND AND OBJECTIVE: Idiopathic, familial and secondary pulmonary arterial hypertension (PAH) are associated with reduced bone morphogenetic protein receptor type 2 (BMPR2) expression, and in some contexts, TGF-β upregulation. Our aims were to assess BMPR2 gene therapy in a PAH mouse model and to assess the impact on TGF-β signalling. METHODS: Using a targeted in vivo gene delivery approach, we assessed the...

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Share to Bone Morphogenetic Protein Receptors, Type II
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Transfer Techniques

Share to Hypertension, Pulmonary

Share to Pulmonary Artery

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Source

Identifiers

PMID: 26689975
DOI: 10.1111/resp.12712

Genes

BMPR2
PAH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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