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Article

Single-cell transcriptomic analysis highlights origin and pathological process of human endometrioid endometrial carcinoma

22 Oct 2022

Abstract excerpt

Endometrial cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states. Current models do not adequately reflect oncogenic origin and pathological progression in patients. Here we use single-cell RNA sequencing to profile cells from normal endometrium, atypical endometrial hyperplasia, and endometrioid endometrial cancer (EEC), which altogether represent the...

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PMID: 36273006
DOI: 10.1038/s41467-022-33982-7

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