Article
High-grade serous tubo-ovarian cancer refined with single-cell RNA sequencing: specific cell subtypes influence survival and determine molecular subtype classification.
Genome medicine - 9 Jul 2021
Olbrecht Siel, Busschaert Pieter, Qian Junbin, Vanderstichele Adriaan, Loverix Liselore, Van Gorp Toon, Van Nieuwenhuysen Els, Han Sileny, Van den Broeck Annick, Coosemans An, Van Rompuy Anne-Sophie, Lambrechts Diether, Vergote Ignace
Abstract excerpt
BACKGROUND: High-grade serous tubo-ovarian cancer (HGSTOC) is characterised by extensive inter- and intratumour heterogeneity, resulting in persistent therapeutic resistance and poor disease outcome. Molecular subtype classification based on bulk RNA sequencing facilitates a more accurate characterisation of this heterogeneity, but the lack of strong prognostic or predictive correlations with these subtypes...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.