Article
Development of human induced pluripotent stem cell-derived neural cultures for seizure-liability testing
2020-01-01
Abstract excerpt
Drug-induced seizure is a major reason for compound attrition during drug development, hence testing the potential of novel agents to induce such neurotoxic events is a vital process. Currently, in vivo and in vitro animal assays are used for seizure-liability studies; yet controversy over the relevance, efficacy and cost of these methodologies has led to interest in the development of human based models, for incr...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 6341707b-2489-5c97-ac1f-f481c00e91ba
- DOI
- 10.48780/publications.aston.ac.uk.00042645