Human IPSC-Derived Microglia Sense and Dampen Hyperexcitability of Cortical Neurons Carrying the Epilepsy-Associated SCN2A-L1342P Mutation.

doi:10.1523/JNEUROSCI.2027-23.2024

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Article

Human IPSC-Derived Microglia Sense and Dampen Hyperexcitability of Cortical Neurons Carrying the Epilepsy-Associated SCN2A-L1342P Mutation.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Jan 2025

Que Zhefu, Olivero-Acosta Maria I, Robinson Morgan, Chen Ian, Zhang Jingliang, Wettschurack Kyle, Wu Jiaxiang, Xiao Tiange, Otterbacher Conrad Max, Shankar Vinayak, Harlow Hope, Hong Seoyong, Zirkle Benjamin, Wang Muhan, Cui Ningren, Mandal Purba, Chen Xiaoling, Deming Brody, Halurkar Manasi, Zhao Yuanrui, Rochet Jean-Christophe, Xu Ranjie, Brewster Amy L, Wu Long-Jun, Yuan Chongli, Skarnes William C, Yang Yang

Abstract excerpt

Neuronal hyperexcitability is a hallmark of epilepsy. It has been recently shown in rodent models of seizures that microglia, the brain's resident immune cells, can respond to and modulate neuronal excitability. However, how human microglia interact with human neurons to regulate hyperexcitability mediated by an epilepsy-causing genetic mutation found in patients is unknown. The SCN2A gene is responsible for...

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PMID: 39557580
DOI: 10.1523/JNEUROSCI.2027-23.2024
PMCID: PMC11735681

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SCN2A

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