Article

Human neural networks with sparse TDP-43 pathology reveal NPTX2 misregulation in ALS/FTLD

2021-12-09

Abstract excerpt

Human cellular models of neurodegeneration require reproducibility and longevity, which is necessary for simulating these age-dependent diseases. Such systems are particularly needed for TDP-43 proteinopathies 1,2 , which involve human-specific mechanisms 3–6 that cannot be directly studied in animal models. To explore the emergence and consequences of TDP-43 pathologies, we generated iPSC-derived, colony morpho...

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Literature Corpus work: 65c42b15-b10e-564b-b8c9-22d28fd3ea12
DOI: 10.1101/2021.12.08.471089

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