Article

Progranulin loss induces mitochondrial dysfunction and ferroptosis in human cerebral organoids

2025-12-02

Abstract excerpt

Loss-of-function mutations in the granulin ( GRN ) gene cause frontotemporal dementia when the mutations are heterozygous and neuronal ceroid lipofuscinosis, a lysosomal storage disease, when homozygous. While it is well established that disease-causing GRN mutations decrease progranulin (PGRN) levels, leading to neurodegeneration, the cellular and molecular mechanisms underlying these conditions remain poorly u...

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Literature Corpus work: b4bf2dea-d573-5e43-8f96-fd710dd3bea0
DOI: 10.64898/2025.11.29.691344

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