Article

Rational design and adaptive management of combination therapies for Hepatitis C virus infection

2014-08-27

Abstract excerpt

Recent discoveries of direct acting antivirals against Hepatitis C virus (HCV) have raised hopes of effective treatment via combination therapies. Yet rapid evolution and high diversity of HCV populations, combined with the reality of suboptimal treatment adherence, make drug resistance a clinical and public health concern. We develop a general model incorporating viral dynamics and pharmacokinetics/pharmacodynami...

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Literature Corpus work: 99b07f52-27f5-5ae9-8e6c-23b4aecdc023
DOI: 10.1101/008466

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