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Article

A multi-variant, viral dynamic model of genotype 1 HCV to assess the in vivo evolution of protease-inhibitor resistant variants.

PLoS computational biology - 15 Apr 2010

Adiwijaya Bambang S, Herrmann Eva, Hare Brian, Kieffer Tara, Lin Chao, Kwong Ann D, Garg Varun, Randle John C R, Sarrazin Christoph, Zeuzem Stefan, Caron Paul R

Abstract excerpt

Variants resistant to compounds specifically targeting HCV are observed in clinical trials. A multi-variant viral dynamic model was developed to quantify the evolution and in vivo fitness of variants in subjects dosed with monotherapy of an HCV protease inhibitor, telaprevir. Variant fitness was estimated using a model in which variants were selected by competition for shared limited replication space. Fitness...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20419154
DOI: 10.1371/journal.pcbi.1000745
PMCID: PMC2855330

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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