Article
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
Chemical reviews - 24 Mar 2021
Matthew Ashley N, Leidner Florian, Lockbaum Gordon J, Henes Mina, Zephyr Jacqueto, Hou Shurong, Rao Desaboini Nageswara, Timm Jennifer, Rusere Linah N, Ragland Debra A, Paulsen Janet L, Prachanronarong Kristina, Soumana Djade I, Nalivaika Ellen A, Kurt Yilmaz Nese, Ali Akbar, Schiffer Celia A
Abstract excerpt
Drug resistance is prevalent across many diseases, rendering therapies ineffective with severe financial and health consequences. Rather than accepting resistance after the fact, proactive strategies need to be incorporated into the drug design and development process to minimize the impact of drug resistance. These strategies can be derived from our experience with viral disease targets where multiple...
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