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Article

Modeling viral kinetics and treatment outcome during alisporivir interferon-free treatment in hepatitis C virus genotype 2 and 3 patients.

Hepatology (Baltimore, Md.) - 1 May 2014

Guedj Jeremie, Yu Jing, Levi Micha, Li Bin, Kern Steven, Naoumov Nikolai V, Perelson Alan S

Abstract excerpt

UNLABELLED: Alisporivir (ALV) is a cyclophilin inhibitor with pan-genotypic activity against hepatitis C virus (HCV). Here, we characterize the viral kinetics observed in 249 patients infected with HCV genotypes 2 or 3 and treated for 6 weeks with different doses of ALV with or without ribavirin (RBV). We use this model to predict the effects of treatment duration and different doses of ALV plus RBV on sustained...

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PMID: 24375768
DOI: 10.1002/hep.26989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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