Article

<i>U1</i>snRNA mutation reshapes tumor microenvironment in chronic lymphocytic leukemia: a role for CD44-mediated signaling

2025-04-01

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of monoclonal mature B lymphocytes in peripheral blood, bone marrow, lymphoid tissues, and extranodal sites. Genes involved in RNA splicing such as SF3B1 and U1 are frequently mutated in CLL, leading to altered splicing and generation of tumor neoepitopes. To study the impact of these mutations on the tumor microenvironment (TME), we have deve...

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Literature Corpus work: 99af45e8-fce3-5ecc-92a7-058d0e850e3f
DOI: 10.1101/2025.03.31.25324954

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