Article

Cross-gene kinase domain hotspot analysis with AI pathogenicity prediction identifies FGFR2 D650G as a candidate actionable variant

2026-07-03

Abstract excerpt

<title>Abstract</title> <p>Variants of unknown significance (VUSs) constitute most variants detected by cancer genomic profiling, limiting the clinical application of precision oncology. We developed a systematic framework that integrates cross-gene mutation mapping across 41 receptor tyrosine kinase genes with AI-driven pathogenicity prediction. By mapping 32,462 kinase-domain mutations from the AACR Project GEN...

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Literature Corpus work: 78a8467a-4dae-52b0-9d8a-e646ff7d51c0
DOI: 10.21203/rs.3.rs-10221428/v1

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