Article

α7 nicotinic acetylcholine receptors regulate radial glia fate in the developing human cortex

2025-04-10

Abstract excerpt

Prenatal nicotine exposure impairs fetal cortical grey matter volume, but the precise cellular mechanisms remain poorly understood. This study elucidates the role of nicotinic acetylcholine receptors (nAChRs) in progenitor cells and radial glia (RG) during human cortical development. We identify two nAChR subunits—CHRNA7 and the human-specific CHRFAM7A—expressed in SOX2+ progenitors and neurons, with CHRFAM7A part...

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Literature Corpus work: 9975c709-a93e-5dc8-936d-7cfb5bd4b96d
DOI: 10.1101/2025.04.10.647795

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