Article

Plasma Lipid Alterations Track Multidimensional Psychosis Severity Across Diagnostic Boundaries

2026-02-26

Abstract excerpt

<h4>Background</h4> Lipidomic alterations have been reported across schizophrenia (SCZ) and bipolar disorder (BD), but findings are heterogeneous and often overlap across diagnoses, limiting diagnostic specificity. Associations between lipid profiles and illness severity have also been inconsistent when assessed using single symptom scales, raising the possibility that unidimensional measures fail to capture biol...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 997381ce-5ce9-5aea-8cc9-56442914fc29
DOI: 10.64898/2026.02.24.26346956

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Plasma Lipid Alterations Track Multidimensional Psychosis Severity Across Diagnostic BoundariesDOI 10.64898/2026.02.24.26346956Read

Plasma Lipid Alterations and Polygenic Risk Track Multidimensional Psychosis Severity Across Classical Diagnostic BoundariesSemantic proximity Read

Dysregulated lipid metabolism precedes onset of psychosis in people at clinical high riskSemantic proximity Read

Disorder-specific and shared genetic architecture underlying schizophrenia and bipolar disorderSemantic proximity Read

The lipidome in major depressive disorder: Shared genetic influence for ether-phosphatidylcholines, a plasma-based phenotype related to inflammation, and disease risk.Semantic proximity Read

Polygenic risk scores across the extended psychosis spectrum.Semantic proximity Read

Penetrance and pleiotropy of polygenic risk scores for schizophrenia in 106,160 patients across four healthcare systemsSemantic proximity Read

Identifying circulating protein targets for common factors underlying schizophrenia, depression, and bipolar disorderSemantic proximity Read

Transdiagnostic Effects of Schizophrenia Polygenic Scores on Treatment Outcomes in Major Psychiatric DisordersSemantic proximity Read

Biotyping in psychosis: using multiple computational approaches with one data set.Semantic proximity Read

Supervised machine learning classification of psychosis biotypes based on brain structure: findings from the Bipolar-Schizophrenia network for intermediate phenotypes (B-SNIP).Semantic proximity Read

Polygenic risk score and the psychosis continuum model.Semantic proximity Read

Strategies for Advancing Disease Definition Using Biomarkers and Genetics: The Bipolar and Schizophrenia Network for Intermediate Phenotypes.Semantic proximity Read