Article

Plasma Lipid Alterations and Polygenic Risk Track Multidimensional Psychosis Severity Across Classical Diagnostic Boundaries

2026-07-09

Abstract excerpt

<title>Abstract</title> <p>Schizophrenia (SCZ) and bipolar disorder (BD) are characterised by pervasive clinical heterogeneity, compromising biological discovery and individualized treatment. Data-driven clustering has identified a transdiagnostic severe psychosis subtype marked by high psychotic symptom load, cognitive impairment, and poor functioning, yet its biological underpinnings remain to be understood. To...

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Literature Corpus work: 0cc0086c-e632-5cf8-9f05-b25f4b2ee83b
DOI: 10.21203/rs.3.rs-9605572/v1

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