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Article

Evaluation of Bayesian Linear Regression models for gene set prioritization in complex diseases.

PLoS genetics - 1 Nov 2024

Gholipourshahraki Tahereh, Bai Zhonghao, Shrestha Merina, Hjelholt Astrid, Hu Sile, Kjolby Mads, Rohde Palle Duun, Sørensen Peter

Abstract excerpt

Genome-wide association studies (GWAS) provide valuable insights into the genetic architecture of complex traits, yet interpreting their results remains challenging due to the polygenic nature of most traits. Gene set analysis offers a solution by aggregating genetic variants into biologically relevant pathways, enhancing the detection of coordinated effects across multiple genes. In this study, we present and...

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Identifiers

PMID: 39495786
DOI: 10.1371/journal.pgen.1011463
PMCID: PMC11563439

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