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Article

Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts.

PLoS genetics - 1 Nov 2013

Silver Matt, Chen Peng, Li Ruoying, Cheng Ching-Yu, Wong Tien-Yin, Tai E-Shyong, Teo Yik-Ying, Montana Giovanni

Abstract excerpt

Standard approaches to data analysis in genome-wide association studies (GWAS) ignore any potential functional relationships between gene variants. In contrast gene pathways analysis uses prior information on functional structure within the genome to identify pathways associated with a trait of interest. In a second step, important single nucleotide polymorphisms (SNPs) or genes may be identified within...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24278029
DOI: 10.1371/journal.pgen.1003939
PMCID: PMC3836716

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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