Article

The KHK–Polyol Axis as a Convergent Energetic Bottleneck in Chronic Disease Persistence

2026-02-16

Abstract excerpt

BACKGROUND: Despite decades of focus on caloric intake and insulin signaling, the global rates of metabolic and neurodegenerative diseases continue to rise. This suggests a fundamental “missing link” in our understanding of cellular energy metabolism. Although various stressors instigate disease, a model that identifies a convergent mechanism capable of preventing cellular recovery across diverse pathologies is la...

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Literature Corpus work: 99530071-44de-541e-8da1-9f58262ba5a5
DOI: 10.32388/r2nfg9

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