Endocrine-Microbial Trade-offs under Extreme Cold and Physical Stress: Multi-omics Network Reveals Tryptophan/Lipid Reprogramming and the Cost of Cortisol Overload

Abstract excerpt

<title>Abstract</title> <p> The dual burden of extreme cold exposure and high-intensity physical exertion imposes profound physiological stress, challenging metabolic homeostasis and neuroendocrine stability. While the gut microbiota mediates energy harvesting, its systemic regulatory role and the physiological costs of maintaining a high-endurance phenotype under extreme stress remain poorly elucidated. This st...

Topics

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• Adipose Tissue and Metabolism
• Diet and metabolism studies
• Endoplasmic Reticulum Stress and Disease
• Genetics, Aging, and Longevity in Model Organisms
• Gut microbiota and health
• Muscle metabolism and nutrition
• Telomeres, Telomerase, and Senescence
• Zoonotic diseases and public health

Identifiers and source

Literature Corpus work

7f7b0217-2a00-56ce-8611-d24db750be05

DOI

10.21203/rs.3.rs-9867495/v1