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From adaptation to exhaustion: defining exposure-related malnutrition as a bioenergetic phenotype of aging.

Biogerontology - 13 Aug 2025

Tippairote Torsak, Hoonkaew Pruettithada, Suksawang Aunchisa, Tippairote Prayfan

Abstract excerpt

Aging is increasingly understood not as the passive accumulation of molecular damage, but as the cumulative cost of unresolved physiological adaptation under bioenergetic constraint. This review introduces Exposure-Related Malnutrition (ERM) as a mechanistically grounded and clinically actionable phenotype of early maladaptation. ERM arises from sustained metabolic strain during chronic stress exposure and...

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PMID: 40802114
DOI: 10.1007/s10522-025-10302-2

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