Article

Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasis

2024-12-12

Abstract excerpt

Hepatic lipid accumulation, or Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD), is a significant risk factor for liver cancer. Despite the rising incidence of MASLD, the underlying mechanisms of steatosis and lipotoxicity remain poorly understood. Interestingly, lipid accumulation also occurs during fasting, driven by the mobilization of adipose tissue-derived fatty acids into the liver. However,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 99498207-cfbb-5e45-9876-b349733516f7
DOI: 10.1101/2024.12.10.627730

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spatially resolved rewiring of mitochondria-lipid droplet interactions in hepatic lipid homeostasisDOI 10.1101/2024.12.10.627730Read

Hepatic lipid droplets: A balancing act between energy storage and metabolic dysfunction in NAFLD.Semantic proximity Read

Interorganelle competition for linoleic acid underlies steatotic liver pathologySemantic proximity Read

A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signalingSemantic proximity Read

MTARC1 Regulates Lipid Droplet Degradation via Phospholipid Remodeling in Metabolic Fatty Liver DiseaseSemantic proximity Read

Holistic Characterization of Single Hepatocyte Transcriptome Responses to High Fat DietSemantic proximity Read

Multi-omics profiling reveals altered mitochondrial metabolism in adipose tissue from patients with metabolic dysfunction-associated steatohepatitisSemantic proximity Read

Tripartite ER-Mitochondria-Lipid Droplets contact sites control adipocyte metabolic flexibilitySemantic proximity Read

Mechanisms of Lipid Droplet Accumulation in Steatotic Liver DiseasesSemantic proximity Read

Lipidomics Analyses Reveal Temporal and Spatial Lipid Organization and Uncover Daily Oscillations in Intracellular Organelles.Semantic proximity Read

The fatty liver disease-causing protein PNPLA3-I148M alters lipid droplet-Golgi dynamicsSemantic proximity Read

A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liverSemantic proximity Read

Nutrient State, Aging, and Diet Modulate SAM50-Dependent Mitochondrial Remodeling and Systemic Metabolic SignaturesSemantic proximity Read