Article

Tripartite ER-Mitochondria-Lipid Droplets contact sites control adipocyte metabolic flexibility

2025-09-18

Abstract excerpt

Obesity is a major risk factor for cardiometabolic diseases, with adipocyte dysfunction playing a central role. Understanding how lipid storage and mobilization are regulated—and disrupted—in adipocytes is key to addressing obesity-associated complications. The ER-anchored protein Seipin controls lipid droplet (LD) biogenesis and maintenance, and its loss disrupts ER–LD contact sites. In humans, Seipin deficiency...

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Literature Corpus work: bf2a7e8d-7398-53fd-8ce0-ca87e6173cd7
DOI: 10.1101/2025.09.16.676493

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