Article

A spatial map of hepatic mitochondria uncovers functional heterogeneity shaped by nutrient-sensing signaling

2023-04-13

Abstract excerpt

In the liver, mitochondria are exposed to different concentrations of nutrients due to their spatial positioning across the periportal (PP) and pericentral (PC) axis. How these mitochondria sense and integrate these signals to respond and maintain homeostasis is not known. Here, we combined intravital microscopy, spatial proteomics, and functional assessment to investigate mitochondrial heterogeneity in the contex...

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Literature Corpus work: 11ac1db3-eef6-538a-bae5-1d992941ebb1
DOI: 10.1101/2023.04.13.536717

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