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Pan-cancer mapping of differential protein-protein interactions.

Scientific reports - 24 Feb 2020

Gulfidan Gizem, Turanli Beste, Beklen Hande, Sinha Raghu, Arga Kazim Yalcin

Abstract excerpt

Deciphering the variations in the protein interactome is required to reach a systems-level understanding of tumorigenesis. To accomplish this task, we have considered the clinical and transcriptome data on >6000 samples from The Cancer Genome Atlas for 12 different cancers. Utilizing the gene expression levels as a proxy, we have identified the differential protein-protein interactions in each cancer type and...

Topics

Algorithms
Biomarkers, Tumor
Cell Line, Tumor
Gene Expression Profiling
Gene Expression Regulation, Neoplastic
Genome, Human
Humans
Kaplan-Meier Estimate
Neoplasm Metastasis
Neoplasms
Phenotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Principal Component Analysis

Prognosis

Protein Interaction Mapping

Protein Interaction Maps

Transcriptome

Source

Open in PubMed Open full text

Identifiers

PMID: 32094374
DOI: 10.1038/s41598-020-60127-x
PMCID: PMC7039988

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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