Article

Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers

2025-04-10

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease resulting in paralysis and death within three to five years. Mutations in over forty different proteins have been linked to ALS, leading to controversy whether ALS is one disease or many diseases with a similar phenotype. Mutations in Cu,Zn superoxide dismutase 1 (SOD1) are only found in 2-3% of ALS cases, yet misfolded SOD1 is found in...

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Literature Corpus work: 990016d8-c890-5d92-a404-8298c5fda6be
DOI: 10.1101/2025.04.07.647611

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