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Article

Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 5 Jan 2005

Turner Bradley J, Atkin Julie D, Farg Manal A, Zang Da Wei, Rembach Alan, Lopes Elizabeth C, Patch Justin D, Hill Andrew F, Cheema Surindar S

Abstract excerpt

Mutations in the intracellular metalloenzyme superoxide dismutase 1 (SOD1) are linked to neurotoxicity in familial amyotrophic lateral sclerosis (ALS) by an unclear mechanism. Golgi fragmentation and endoplasmic reticulum stress are early hallmarks of spinal motor neuron pathology in transgenic mice overexpressing mutant SOD1, suggesting that dysfunction of the neuronal secretory pathway may contribute to ALS...

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Source

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Identifiers

PMID: 15634772
DOI: 10.1523/JNEUROSCI.4253-04.2005
PMCID: PMC6725218

Genes

SOD1
SOD3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Impaired extracellular secretion of mutant superoxide dismutase 1 associates with neurotoxicity in familial amyotrophic lateral sclerosis.PMID 15634772Read ↗

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